TOP TIERMARKET NEWSWIRE
Movers explained · 2026-10-07

Archived explainer. For the current picture see today's TWST page.

Why Is TWIST BIOSCIENCE COR (TWST) Stock Down Today?

By the Top Tier Newswire AI Desk · October 7, 2026 at 9:57 AM ET · reviewed against 3 wire stories

TWIST BIOSCIENCE COR (TWST) is down -6.60% in the latest session. Our newswire has captured 3 stories on TWST across 2 sources in the last 36 hours, with AI sentiment reading mixed (avg 46/100).

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TWST stock fell 6.60% to $155.96 in early trading on Monday, marking a sharp reversal after the biotech firm had reached a 52-week high just days earlier. The decline followed a -2.0% opening gap and a steady drop through the session. The move comes amid mixed analyst coverage and recent insider selling, despite several brokerages having raised price targets for the stock in recent weeks.

What Happened

The stock opened at $163.65, a $3.32 drop from the previous close, and quickly moved lower throughout the session. By 9:30 AM ET, it had fallen to $154.62, its lowest level of the day. The decline came despite recent analyst upgrades, including a $215 price target from Barclays and $190 from Leerink Partners. However, the stock had already fallen -12.7% in a previous session, raising concerns among investors. The drop on Monday appears to reflect broader market sentiment and ongoing pressure from heavy insider selling, with three executives reporting sales totaling $118.9 million in the past 90 days.

What The Data Shows

The stock has traded between $23.30 and $219.71 over the past 52 weeks, with a current market cap of $12.9 billion. Despite a 19.2% year-to-date revenue increase, the company remains unprofitable, with a trailing 12-month net margin of -31.7%. The recent session saw 0.9 million shares traded, which is 0.4 times the 3-month average. The stock has declined -9.2% over the last 8 sessions, from $183.79 to $166.97. Meanwhile, the 30-day average sentiment score has fallen to 49 from 57, indicating deteriorating investor confidence.

What To Watch

The stock is currently without scheduled earnings, but coverage breadth and analyst price target changes will remain key to watch. Investors should monitor further insider activity and whether the recent analyst upgrades translate into renewed buying interest.

AI-assisted analysis composed exclusively from headlines and data on the Top Tier newswire. Public view is delayed 4 hours from real time. Not financial advice.

TWST by the numbers

Last: $155.96Session: -6.60%7 sessions: -9.15%Coverage: 3 stories / 2 sourcesAI sentiment: 46/100 (mixed)Mkt cap: $12.9B52w: $23.30 to $219.71
TWST · today's session (5-min) · -5.64% vs prior close · updated 3:33 PM ET
$152$160$168prev close $166.97$157.557:00 AM9:07 AM11:15 AM1:22 PM3:30 PM7:00 AM · $163.057:05 AM · $163.657:10 AM · $163.497:15 AM · $163.327:20 AM · $162.507:25 AM · $163.407:40 AM · $163.297:45 AM · $163.007:50 AM · $164.007:55 AM · $163.038:00 AM · $163.118:05 AM · $163.228:10 AM · $163.688:15 AM · $162.028:20 AM · $162.008:25 AM · $159.878:30 AM · $160.008:35 AM · $159.778:40 AM · $159.758:45 AM · $159.908:50 AM · $159.398:55 AM · $159.309:00 AM · $159.309:05 AM · $159.009:10 AM · $159.509:15 AM · $159.609:20 AM · $159.869:25 AM · $158.509:30 AM · $157.869:35 AM · $156.209:40 AM · $159.149:45 AM · $158.559:50 AM · $157.509:55 AM · $157.9010:00 AM · $154.8310:05 AM · $153.2810:10 AM · $154.0810:15 AM · $157.0010:20 AM · $158.4110:25 AM · $157.4410:30 AM · $157.5310:35 AM · $158.3110:40 AM · $160.8110:45 AM · $163.0810:50 AM · $162.9710:55 AM · $163.1011:00 AM · $161.7811:05 AM · $160.8211:10 AM · $163.7211:15 AM · $166.6011:20 AM · $164.1511:25 AM · $165.4711:30 AM · $164.2011:35 AM · $164.0211:40 AM · $163.7511:45 AM · $162.8511:50 AM · $161.3711:55 AM · $160.2212:00 PM · $160.2812:05 PM · $162.6512:10 PM · $160.8512:15 PM · $160.3912:20 PM · $160.9712:25 PM · $161.0012:30 PM · $161.0112:35 PM · $159.3812:40 PM · $159.6012:45 PM · $160.0712:50 PM · $159.3012:55 PM · $159.631:00 PM · $160.021:05 PM · $159.311:10 PM · $158.641:15 PM · $158.311:20 PM · $158.981:25 PM · $158.391:30 PM · $157.971:35 PM · $157.761:40 PM · $157.351:45 PM · $157.661:50 PM · $158.091:55 PM · $158.172:00 PM · $156.842:05 PM · $156.272:10 PM · $155.602:15 PM · $155.982:20 PM · $156.182:25 PM · $157.002:30 PM · $157.492:35 PM · $157.722:40 PM · $156.662:45 PM · $157.132:50 PM · $157.492:55 PM · $157.593:00 PM · $157.833:05 PM · $157.413:10 PM · $157.553:15 PM · $157.403:20 PM · $157.573:25 PM · $157.013:30 PM · $157.55
AI sentiment, last 36h · averaged over 3 stories · 46/100 neutral
AI sentiment 46/100 (neutral)0 · bearish50bullish · 100

The headlines behind the move

Story flow · 3 stories on the wire, last 36h · hover or tap a dot for the headline
36h ago24h ago12h agopublishThe Fly · sentiment 38 · Twist Bioscience falls -12.7%The Fly · 38Twist Bioscience falls -12.7%Investing.com Markets · sentiment 32 · Why is Twist Bioscience stock plunging today?Investing.com Markets · 32Why is Twist Bioscience stock plunging today?The Fly · sentiment 67 · Twist Bioscience price target raised to $215 from $112 at BarclaysThe Fly · 67Twist Bioscience price target raised to $215 from $112 at Barclays
9h agoThe FlyBULLISH 67Analyst

Twist Bioscience price target raised to $215 from $112 at Barclays

1d agoInvesting.com MarketsBEARISH 32General

Why is Twist Bioscience stock plunging today?

Why is Twist Bioscience stock plunging today?

1d agoThe FlyBEARISH 38General

Twist Bioscience falls -12.7%

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More on TWST: full news and sentiment history. Sentiment scores are AI-derived research signals, not financial advice.

Earlier TWST move explainers: 2026-10-07 · 2026-09-17 · 2026-09-16 · 2026-08-20 · 2026-08-19