TOP TIERMARKET NEWSWIRE
Movers explained · November 2, 2026

Why Is KRYSTAL BIOTECH INC (KRYS) Stock Down Today?

By the Top Tier Newswire AI Desk · August 4, 2026 at 12:09 AM ET · reviewed against 9 wire stories

KRYSTAL BIOTECH INC (KRYS) is down -14.40% in the latest session. Our newswire has captured 9 stories on KRYS across 5 sources in the last 36 hours, with AI sentiment reading mixed (avg 52/100).

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KRYS stock fell 8.37% to $312.57 in the session, driven by mixed second-quarter results and investor reaction to guidance. While Krystal Biotech reported GAAP earnings per share of $1.79, which beat estimates by $0.16, revenue of $119.22 million came in $1.82 million below forecasts. The company also outlined a 2026 non-GAAP operating expense range of $175 million to $195 million, and investors appeared to weigh the revenue shortfall and evolving financial commitments.

What Happened

Krystal Biotech reported second-quarter 2026 results on August 3, 2026, with GAAP EPS of $1.79, exceeding the expected $1.63. However, revenue of $119.22 million, while up 24% year over year, fell short of the $121.06 million forecast. The company attributed the revenue miss to timing of VYJUVEK sales and the impact of Germany pricing accruals. Despite robust global VYJUVEK revenue of $119.2 million for the quarter and $965.9 million since launch, the stock declined on concerns over near-term revenue visibility and the outlined expense guidance. The firm also announced it is advancing KB801 into a pivotal trial after discontinuing a clinical study with no safety concerns observed.

What The Data Shows

Krystal Biotech ended the quarter with $1.1 billion in cash and a net margin of 53.9%. The stock has traded between $130.50 and $382.54 over the past 52 weeks. Recent insider transactions include four sales totaling $15.9 million in the last 90 days, with the most recent filing on June 26. Additionally, Donald J. Trump sold between $15,001 and $50,000 in the stock on May 15. The stock’s beta of 0.50 suggests it is less volatile than the broader market, but the sharp intraday move reflects immediate investor reaction to the earnings report and guidance.

What To Watch

The company has no upcoming earnings reports in the near term. Investors should monitor coverage breadth and analyst commentary, particularly as B of A Securities and TD Cowen have both raised price targets to $396 and $403 respectively, maintaining Buy ratings.

AI-assisted analysis composed exclusively from headlines and data on the Top Tier newswire. Public view is delayed 4 hours from real time. Not financial advice.

KRYS by the numbers

Last: $284.43Session: -14.40%7 sessions: +3.14%Coverage: 9 stories / 5 sourcesAI sentiment: 52/100 (mixed)Mkt cap: $10.1BP/E: 45.752w: $130.50 to $382.54
KRYS · today's session (5-min) · -13.67% vs prior close · updated 11:00 AM ET
$279$312$344prev close $332.29$286.887:00 AM8:00 AM9:00 AM10:00 AM11:00 AM7:00 AM · $340.287:05 AM · $311.008:10 AM · $314.109:25 AM · $314.029:30 AM · $310.649:35 AM · $304.069:40 AM · $301.929:45 AM · $297.469:50 AM · $293.069:55 AM · $292.1810:00 AM · $289.3110:05 AM · $286.0510:10 AM · $284.9410:15 AM · $285.3010:20 AM · $286.3010:25 AM · $286.7610:30 AM · $282.8010:35 AM · $287.9010:40 AM · $286.4810:45 AM · $289.0610:50 AM · $289.1110:55 AM · $286.6311:00 AM · $286.88
AI sentiment, last 36h · averaged over 9 stories · 52/100 neutral
AI sentiment 52/100 (neutral)0 · bearish50bullish · 100

The headlines behind the move

Story flow · 9 stories on the wire, last 36h · hover or tap a dot for the headline
36h ago24h ago12h agonowBusiness Insider · sentiment 64 · Krystal Biotech Announces Third Quarter 2026 Financial and Operating ResultsBusiness Insider · 64Krystal Biotech Announces Third Quarter 2026 Financial and Operating ResultsSEC 8-K · sentiment 50 · Krystal Biotech, Inc. (KRYS) files 8-KSEC 8-K · 50Krystal Biotech, Inc. (KRYS) files 8-KThe Fly · sentiment 63 · Krystal Biotech reports Q3 EPS $2.05, consensus $1.92The Fly · 63Krystal Biotech reports Q3 EPS $2.05, consensus $1.92The Fly · sentiment 73 · Krystal Biotech announces $400M share repurchase programThe Fly · 73Krystal Biotech announces $400M share repurchase programSeeking Alpha · sentiment 78 · Krystal Biotech GAAP EPS of $2.05 beats by $0.28, revenue of $1.1B beats by $973.46MSeeking Alpha · 78Krystal Biotech GAAP EPS of $2.05 beats by $0.28, revenue of $1.1B beats by $973.46MInvestorsHub · sentiment 42 · Krystal Biotech Shares Fall 3.7% Despite Q3 Earnings Beat and 30% Revenue GrowthInvestorsHub · 42Krystal Biotech Shares Fall 3.7% Despite Q3 Earnings Beat and 30% Revenue GrowthThe Fly · sentiment 34 · Krystal pipeline catalysts experiencing delays, says RBC CapitalThe Fly · 34Krystal pipeline catalysts experiencing delays, says RBC CapitalThe Fly · sentiment 34 · Krystal Biotech falls -11.7%The Fly · 34Krystal Biotech falls -11.7%Business Insider · sentiment 34 · Krystal Biotech falls as data for pipeline programs pushed to 2027Business Insider · 34Krystal Biotech falls as data for pipeline programs pushed to 2027
12m agoBusiness InsiderBEARISH 34General

Krystal Biotech falls as data for pipeline programs pushed to 2027

Krystal Biotech stock fell after delaying pipeline data to 2027 despite a Q3 earnings beat. Read more here.

56m agoThe FlyBEARISH 34General

Krystal Biotech falls -11.7%

1h agoThe FlyBEARISH 34Analyst

Krystal pipeline catalysts experiencing delays, says RBC Capital

2h agoInvestorsHubBEARISH 42Earnings

Krystal Biotech Shares Fall 3.7% Despite Q3 Earnings Beat and 30% Revenue Growth

Krystal Biotech shares fall 3.7% despite Q3 earnings beating forecasts, with revenue up 30% to $127.34 million on strong VYJUVEK sales.

3h agoSeeking AlphaBULLISH 78Earnings

Krystal Biotech GAAP EPS of $2.05 beats by $0.28, revenue of $1.1B beats by $973.46M

Krystal Biotech Q3 earnings crushed estimates with strong EPS and revenue growth.

3h agoThe FlyBULLISH 73General

Krystal Biotech announces $400M share repurchase program

3h agoThe FlyBULLISH 63Earnings

Krystal Biotech reports Q3 EPS $2.05, consensus $1.92

3h agoSEC 8-KNEUTRAL 50General

Krystal Biotech, Inc. (KRYS) files 8-K

Filed: 2026-11-02 AccNo: 0001711279-26-000072 Size: 591 KB Item 2.02: Results of Operations and Financial Condition Item 9.01: Financial Statements and Exhibits

4h agoBusiness InsiderBULLISH 64Earnings

Krystal Biotech Announces Third Quarter 2026 Financial and Operating Results

$127.3 million in 3Q VYJUVEK global revenue and $1.1 billion since launch VYJUVEK pricing negotiations in Germany and Italy completed

Frequently asked questions

Why is KRYS stock down today?

KRYSTAL BIOTECH INC (KRYS) is down -14.40% in the latest session. Our newswire has captured 9 stories on KRYS across 5 sources in the last 36 hours, with AI sentiment reading mixed (avg 52/100). The most recent driver: "Krystal Biotech falls as data for pipeline programs pushed to 2027" (Business Insider).

Is KRYS a buy right now?

Top Tier Newswire does not give financial advice. Our AI sentiment across the last 36 hours of KRYS coverage reads 52/100 over 9 stories; treat it as a research signal and do your own diligence.

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More on KRYS: full news and sentiment history. Sentiment scores are AI-derived research signals, not financial advice.